Continued Western Medicine Treatment for Lipid-Lowering Diseases: Detailed Explanation of Domestic Statins, Fibrates, and Bile Acid Isolators
> 6. Blood Lipid Relief**
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[Efficacy]This product is a domestically produced lovastatin that can significantly reduce serum total cholesterol, triglycerides, and low-density lipoprotein levels, and has a mild effect of increasing serum high-density lipoprotein levels.
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[Indications]Various types of hyperlipidemia and coronary atherosclerosis.
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> [Usage]The usual dosage is 0.6 grams per day, twice a day.
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> [Precautions]
> (1) After taking the medicine, adverse reactions such as constipation, abdominal distension, abdominal pain, indigestion, muscle pain, muscle weakness, headache and rash may occur.
(2) Increased liver transaminase and creatine kinase levels may be observed during medication, but these levels will recover on their own after discontinuation of the medication.
(3) In very rare cases, patients may develop hepatitis, biliary obstructive jaundice, and allergic reaction syndrome after taking the medication.
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7. Gefitinib (Novo Nordisk)
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[Efficacy]This product is a fibrate lipid-lowering drug that can significantly reduce serum triglyceride levels and also lower serum total cholesterol and increase high-density lipoprotein levels.
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[Indications]Hypertriglyceridemia, hyperlipoproteinemia.
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> [Usage]The usual dosage is 0.9 to 1.2 grams per day, taken 2 to 3 times a day before meals.
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> [Precautions]
> (1) Occasionally, gastrointestinal discomfort reactions such as nausea, vomiting, loss of appetite, diarrhea, abdominal pain and heartburn may occur after taking the medicine.
(2) During medication, transient increases in serum transaminase and creatine kinase may be observed.
> (3) Gallstones may be seen in a very small number of patients.
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**8. Fenofibrate (Lipin)**
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[Efficacy] This product is a fibrate lipid-lowering drug that can significantly reduce serum triglyceride levels and simultaneously lower serum total cholesterol and very low-density lipoprotein while increasing high-density lipoprotein levels.
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> [Indications] Hypertriglyceridemia, mixed hyperlipidemia, hyperlipoproteinemia.
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> [Usage]The standard tablet dosage is 0.1-0.2 grams each time, 2-3 times a day. The stable period dosage is 0.1 grams each time, twice a day.
The usual dosage of micronized formulation is 0.2 grams once daily.
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> [Precautions]
(1) This product is well tolerated, with few and mild adverse reactions.
(2) A few patients may experience upper abdominal discomfort, and occasionally dry mouth, loss of appetite, diarrhea, etc.
(3) A very small number of patients may experience transient elevation of liver transaminases, which will recover spontaneously after discontinuation of the drug.
(4) Not for use by pregnant women.
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**9. Benzafibrate (a lipid-lowering agent)**
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[Efficacy]This product is a fibrate lipid-lowering drug that can effectively reduce serum triglyceride and very low density lipoprotein levels, while also having a certain effect of reducing serum total cholesterol and increasing high density lipoprotein levels.
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[Indications]Hypertriglyceridemia, mixed hyperlipoproteinemia characterized by elevated triglycerides, and diabetes mellitus complicated with hyperlipidemia.
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> [Usage]The usual dose of the regular tablets is 200 mg three times a day. The maintenance dose is 400 mg daily, divided into two doses after meals.
The dosage of the sustained-release tablets is 400 mg once daily, taken after meals.
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> [Precautions]
> (1) After taking the medication, common symptoms include transient nausea, loss of appetite and other gastrointestinal discomfort.
> (2) During medication, elevated serum transaminase levels may be observed, and occasionally myositis-like pain may occur due to elevated serum creatine kinase levels. In such cases, medication should be discontinued immediately.
(3) When this product is used in combination with coumarin anticoagulants, the dosage of the anticoagulant must be reduced.
(4) This product should not be used in combination with statins.
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**10. Ciprofloxacin (Clociprotocin)**
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[Efficacy]This product is a fibrate-based lipid-lowering drug that can effectively reduce serum triglyceride, serum total cholesterol, very low density lipoprotein, and low density lipoprotein levels, while also having a certain effect of increasing high density lipoprotein.
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> [Indications]Hypertriglyceridemia.
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> [Usage]The usual dose is 100 mg once a day.
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> [Precautions]
(1) This product is well tolerated, and adverse reactions are mild and short-lived.
> (2) Occasionally, adverse reactions such as headache, nausea, weakness and rash may occur after taking the medicine.
> (3) Occasionally, serum transaminase and creatine kinase levels may increase during medication.
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**11. Cholestyramine (cholestyramine)**
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[Efficacy]This product is a bile acid inhibitor that can significantly reduce serum total cholesterol levels and reduce the incidence and mortality of coronary heart disease.
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[Indications]Hypercholesterolemia, coronary heart disease.
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> [Usage]The usual dosage is 4-5 grams per day, and the maximum daily dosage shall not exceed 24 grams.
> In the initial stage of medication, it is necessary to start with a small dose, and the maximum tolerated dose can be reached within 1 to 3 months after starting medication.
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> [Precautions]
> (1) High doses can easily cause gastrointestinal discomfort symptoms such as nausea, vomiting, abdominal distension, upper abdominal discomfort and constipation.
> (2) Severe adverse reactions, such as steatorrhea, severe abdominal pain, and intestinal obstruction.
(3) This product can interfere with the body's absorption of folic acid, digoxin, warfarin, fibrates, statins, and fat-soluble vitamins; therefore, it is necessary to supplement vitamin A, vitamin D, vitamin E, and vitamin K during the medication period.
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**12. Cholecystokinin (Choledochoton)**
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[Efficacy]This product is a bile acid inhibitor that can effectively reduce serum total cholesterol and low-density lipoprotein levels.
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> [Indications]Hypercholesterolemia.
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> [Usage]The usual dosage is 4-5 grams each time, 2-3 times a day.
When taking this medicine, mix it with water or a beverage and take it before meals or before bedtime each day.
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> [Precautions]
> (1) High doses can easily cause gastrointestinal discomfort symptoms such as nausea, vomiting, abdominal distension and upper abdominal discomfort, while constipation is less common.
> (2) Severe adverse reactions, such as steatorrhea, severe abdominal pain, and intestinal obstruction.
(3) This product can interfere with the body’s absorption of folic acid, digoxin, warfarin, fibrates, statins, and fat-soluble vitamins. Therefore, it is necessary to supplement vitamin A, vitamin D, vitamin E, and vitamin K during the medication period.
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